Edna Skinner

Edna Skinner was an American film and television actress notable for playing Kay Addison, neighbor of Wilbur Post, in the iconic TV series Mister Ed. Her character was replaced months after her onscreen husband died according to Alan Young in his Archive of American Television interview, the writers tried to make her a widow on the show, but finally decided to bring in another married couple, Gordon and Winnie Kirkwood, played by Leon Ames and Florence MacMichael, and Edna Skinner had to leave the show.

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Source: Wikipedia